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KMID : 1161420200230101070
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Journal of Medicinal Food
2020 Volume.23 No. 10 p.1070 ~ p.1076
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Genomic Instability Decreases in HIV Patient by Complementary Therapy with Rosmarinus officinalis Extracts
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Lazalde-Ramos Blanca Patricia
Zamora-Perez Ana Lourdes
Ortega-Guerrero Aymee Ileana
Quintero-Fraire Saira Zulema
Palacios-Lara Omar
Quirarte-Baez Sol Maria
Galaviz-Hernandez Carlos
Sosa-Macias Martha
Ortiz-Garcia Yveth Marlene
Morales-Velazquez Gabriela
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Abstract
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Genomic instability is associated with increased oxidative stress in patients with human immunodeficiency virus (HIV). The aim of this study was to determine the effect of intake of methanolic and aqueous extracts of Rosmarinus officinalis on genomic instability in HIV patients. We studied 67 HIV patients under pharmacological treatment with ATRIPLA who were divided into three groups: group 1, patients under ATRIPLA antiretroviral therapy; group 2, patients with ATRIPLA and rosemary aqueous extract (4?g/L per day); and group 3, patients with ATRIPLA and rosemary methanolic extract (400?mg/day). The genomic instability was evaluated through the buccal micronucleus cytome assay. Oral epithelial cells were taken at the beginning and 1 and 4 months later. The groups that received the pharmacological therapy with ATRIPLA and the complementary therapy with R. officinalis extracts showed a decrease in the number of cells with micronuclei and nuclear abnormalities compared with the group that only received ATRIPLA. The complementary therapy with R. officinalis decreased the genomic instability in HIV patients.
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KEYWORD
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cytotoxicity, DNA instability, genotoxicity, HIV, nuclear abnormalities, Rosmarinus officinalis
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